A novel method to detect circulating histones H3 and H2B in plasma for its clinical application in critical bacteriaemic septic shock patients.
EpiDisease rceives CDTI funding for HistSHOCK CDx
This long-term analysis underscores the power of sustained, multidisciplinary sepsis protocols and highlights the next frontier: AI-driven prediction.
Extracellular histones, primarily nuclear proteins involved in chromatin organization, have emerged as key mediators in pathological processes in critically ill patients
Sepis biomarkers history
García‑Giménez et al. Journal of Translational Medicine (2023) 21:344 A step closer to a robust applied biomarker for the diagnosis
Beltrán-García J, Osca-Verdegal R, Romá-Mateo C, et al. Epigenetic biomarkers for human sepsis and septic shock: insights from immunosuppression [published