This study developed a targeted mass spectrometry method (MRM-MS) to detect and quantify circulating histones H3 and H2B in plasma from septic shock patients. The results showed significantly higher histone levels in patients مقارنة to healthy controls, supporting their role as diagnostic biomarkers. Moreover, elevated histone levels—particularly H3—were associated with poorer outcomes, indicating prognostic value. Overall, the method demonstrated accuracy and potential for early diagnosis and outcome prediction in septic shock.

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