Arrays Illumina

Driving the next era of genomics

Illumina microarray technology (also known as BeadChips) uses silica microspheres. These microspheres are housed in microwells carefully etched into the surface of each BeadChip array and are coated with multiple copies of an oligonucleotide probe so that each position targets a specific locus in the genome.

Each array can simultaneously analyze hundreds of thousands to millions of positions in the genome of the corresponding species.

Illumina offers formats ranging from 8 to 48 samples/array, making it a highly versatile and powerful tool.

How do Illumina microarryas work?

As DNA fragments pass through the BeadChip, each probe binds to a complementary sequence in the sample DNA, stopping one base before the locus of interest. Allele specificity is conferred by a single-base extension that incorporates one of four labeled nucleotides. When excited by a laser, the labeled nucleotide emits a signal. The intensity of that signal conveys information about the allele ratio at that locus.

The advantages of Illumina arrays

Enable large-scale genetic and epigenetic studies to be carried out at a reasonable cost and within a reasonable time frame.
The quality control built into the system provides highly reliable and reproducible data.
The extensive catalog of microarrays allows them to be used in initiatives as diverse as precision medicine, clinical and translational research, pharmacology, consumer screening, and agricultural and livestock applications.
Large number of predefined array types for various species, with the possibility of adding custom panel designs for specific research needs.
The widespread use of this technology encourages collaboration and accelerates research.
In addition to SNPs, it also detects chromosomal alterations and copy number variations (CNVs) simultaneously on the same array.
The workflow allows studies to be scaled from a few samples to large population studies.
Capability of integration with Illumina sequencing systems for multi-omic analysis.
It has integrated tools for laboratory management, tracking, and traceability.

Our latest arrival: the TECAN robot

EpiDisease has the IAPS (Infinium Automated Pipetting System) platform, a high-precision instrument that automates specific steps in Illumina Infinium array workflows.

This automation results in:

a significant increase in throughput,
a reduction in manual handling time, and
greater experimental reproducibility,

enabling extensive studies that were previously very costly to be carried out.

EpiDisease has expanded its capacity to process all types of arrays detailed in the table below:

BovineHD DNA Analysis

Bovine genome SNP genotyping array

8 samples/array

Infinium HD

DNA: Bos taurus taurus

777.962 SNPs unifromly distributed throughout the genome

Whole genome studies
Identification of quantitative trait loci
Genetic quality assessment
Cross mapping
Linkage disequilibrium studies
Comparative genetic studies

BovineSNP50 v3 DNA Analysis

Array with SNPs validated in 18 common beef and dairy cattle breeds

24 samples/array

Infinium HTS

DNA: Bos taurus taurus

53,218 highly informative SNPs evenly distributed across the genome with an average spacing of 37.4 Kb

Genomic selection
Identification of quantitative trait loci
Genetic quality assessment

Infinium Asian Screening Array-24 v1.0

Array with informative markers for East and Southeast Asian populations that are underrepresented in reference populations

Infinium HTS

DNA: Human

659.184 markers:

SNPs
Indels
CNVs

Population studies
Studies of complex diseases
Pharmacogenetic studies

Infinium Core-24 Kit

Cost-effective array for large-scale projects.

24 samples/array

Infinium HTS

DNA: Human

307.342 markerss:

SNPs
Germline variants
Structural variants
Indels
CNVs

Common variant studies
Ancestry studies
Sex confirmation
Variant loss
Indel studies
CNV detection

Infinium CytoSNP-850K Bead Chip

High-resolution array for the study of chromosomal aberrations in 3,262 genes relevant to cancer research

8 samples/array

Infinium HD

DNA: Human

848.000 SNPs
3262 genes sensitive to dose

CNVs
Loss of heterozygosity

Infinium Exome-24 Kit

Array of selected exonic variants from 12,000 human exomes and WGS

24 samples/array

Infinium HTS

DNA: Human

244,883 markers representing diverse populations and various common diseases, cancer, metabolic and psychiatric disorders

New studies of previously genotyped cohorts
Studies identifying functionally relevant associations

Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit

Array designed for pharmacogenomics (PGx) and large-scale genotyping studies

24 samples/array

Infinium EX

DNA: Human

1,185,155 SNP markers:

Structural variants
SNVs
Indels
CNVs

Large-scale pharmacogenomics studies
Large-scale genotyping studies

Infinium Global Clinical Research Array-24 v1.0 kit

Cost-effective genotyping array for clinical research studies

24 samples/array

Infinium EX

DNA: Human

1.157.992 markers:

SNPs
Indels

Clinical research studies
Population studies
Molecular blood typing studies

Infinium Global Diversity Array with Carrier Screening Content-8 v2.0 kit

Cost-effective array for pan-ethnic screening studies of carriers of 602 genes

8 samples/array

Infinium LCG

DNA: Human

1,870,000 markers (45,000 carrier screening markers recommended by the ACMG)

SNPs
CNVs

Screening for carriers of recessive and X-linked diseases

Infinium Global Diversity Array with Cytogenetics-8

Array for cytogenetic studies

8 samples/array

Infinium LCG

DNA: Human

1.800.000 markers:

SNPs
Loss of heterozygosity
Chromosomal abnormalities
CNVs

Detection of structural variants:

duplications, deletions, loss of heterozygosity, and mosaicism
Studies of cytogenetic changes in constitutional diseases, cancer, etc.
Detection and validation studies

Infinium Global Diversity Array with Enhanced PGx

Comprehensive genotyping array for pharmacogenomic research

8 samples/array

Infinium LCG

DNA: Human

1.933.117 markers:

SNPs
CNVs
Targeted amplification for pseudogene disambiguation

Pharmacogenomics research
Polygenic risk studies
Ancestry determination
Genetic disease research

Infinium Global Diversity Array with Polygenic Risk Score Content-8 v1.0

Flexible array for PRS (Polygenic Risk Score) studies

8 samples/array

Infinium LCG

DNA: Human

2.028.571 markers:

SNPs
Mitochondrial
Indels
Sex chromosomes
Pseudoautosomal regions (PAR)

Studies of polygenic diseases (diabetes, cancer, coronary heart disease, Alzheimer’s disease, etc.)
Pan-ethnic GWAS studies

Infinium Global Diversity Array-8 kit

Cost effective multiethnic array

8 samples/array

Infinium LCG

DNA: Human

1.825.277 markers:

SNPs
Mitochondrial
Indels
Sex chromosomes
Pseudoautosomal regions (PAR)

Pharmacogenomic studies associated with absorption, distribution, metabolism, and excretion phenotypes based on PharmGKB17

Infinium Global Screening Array with Enhanced PGx-48 v4.0 Kit

High-throughput genotyping array with automated workflow

48 samples/array

Infinium EX

DNA: Human

656.275 markers:

SNPs
Mitochondrial
Indels
Sex chromosomes
Pseudoautosomal regions (PAR)

High-throughput population studies
Research in pharmacogenomics and precision medicine

Infinium Global Screening Array with Cytogenetics-24

Cost-effective array for whole-genome cytogenetic analysis

24 samples/array

Infinium HTS

DNA: Human

700.000 markers

Detection of CNVs in constitutional diseases and cancer

Infinium Global Screening Array with Enhanced PGx-48 v4.0 Kit

High-throughput genotyping array with automated workflow

48 samples/array

Infinium EX

DNA: Human

656.275 markers:

SNPs
Mitochondrial
Indels
Sex chromosomes
Pseudoautosomal regions (PAR)

High-throughput population studies
Research in pharmacogenomics and precision medicine

Infinium Global Screening Array-24 kit

High-throughput genotyping array with automated workflow capability

24 samples/array

Infinium HTS (v3.0)

DNA: Human

654.027 markers

High-throughput population genetics studies
Variant screening
Precision medicine studies

Infinium Global Screening Array-48 kit

High-throughput genotyping array with automated workflow capability

48 samples/array

Infinium EX

DNA: Human

650.231 markers

High-yield population genetics studies
Precision medicine studies

Infinium HTS iSelect Custom Beadchips

Fully customized array with access to any marker/species, fully customized for any research

24 samples/array

Infinium HTS

DNA: any species

Fully customized assays for any SNP, any genome, and any species

Infinium ImmunoArray-24 v2 BeadChip Kit

High-performance array for detecting genetic variants in the immune system

24 samples/array

Infinium HTS

DNA: Human

253.702 markers specific to the human immune system

Focused on 17 autoimmune diseases

Infinium Methylation Screening Array-48 Kit

Array focused on methylation markers associated with common human traits

48 samples/array

Infinium EX

DNA: Human

269.094 CpG islands. CpH, SNPs

MSA Studies
Research into the most common diseases (excluding cancer)
Environmental epidemiology
Population genomic
Consumer genomics (ancestry, biological age, etc.)

Infinium MethylationEPIC v2.0 Kit

Whole-genome methylation arrays

8 samples/array

Infinium HD

DNA: Human

935.000 methylation markers

Whole genome methylation analysis
Research into rare genetic diseases
Cancer research

Infinium Mouse Methylation BeadChip

Methylation arrays of murine strains used in research laboratories

12 samples/array

Infinium HD

DNA: Mouse

285.000 methylation markers

Studies of DNA methylation changes in murine strains

Infinium Omni5-4 Kit

Array covering the entire genome with high coverage in global superpopulations

4 samples/array

Infinium LCG

DNA: Human

4.327.108 marcadores de:

SNPS
Variantes estructurales y de línea germina
Indels
CNVs

Whole genome genotyping
CNV studies

Infinium OmniExpress-24 Kit

Customizable array for high-throughput genotyping studies

24 samples/array

Infinium HTS

DNA: Human

717.960 markers

GWAS studies

Infinium OncoArray-500K BeadChip

Array developed by the “OncoArray” consortium

24 samples/array

Infinium HTS

DNA: Human

499.170 markers

Studies of the most common cancers: breast, colorectal, lung, ovarian, and prostate

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