Adolescent idiopathic scoliosis (AIS), the most common pediatric spinal disorder, lacks an obvious cause and is characterized by an abnormal spinal curve.

While research has linked some cases to genetic factors like collagen and cartilage defects, the underlying biology is not fully understood, which hinders the development of effective treatments.

In this papaer the authors interrogate the downstream causes of scoliosis in the dominant SCO-spondin (sspodmh4/+) mutant zebrafish model of AIS15.