Arrays Illumina

Driving the next era of genomics

Illumina microarray technology (also known as BeadChips) uses silica microspheres. These microspheres are housed in microwells carefully etched into the surface of each BeadChip array and are coated with multiple copies of an oligonucleotide probe so that each position targets a specific locus in the genome.

Each array can simultaneously analyze hundreds of thousands to millions of positions in the genome of the corresponding species.

Illumina offers formats ranging from 8 to 48 samples/array, making it a highly versatile and powerful tool.

How do Illumina microarrays work?

As DNA fragments pass through the BeadChip, each probe binds to a complementary sequence in the sample DNA, stopping one base before the locus of interest. Allele specificity is conferred by a single-base extension that incorporates one of four labeled nucleotides. When excited by a laser, the labeled nucleotide emits a signal. The intensity of that signal conveys information about the allele ratio at that locus.

The advantages of Illumina arrays

They enable large-scale genetic and epigenetic studies to be carried out at a reasonable cost and within a reasonable time frame.

The quality control support integrated into the system provides highly reliable and reproducible data.

The extensive catalog of microarrays allows them to be used in initiatives as diverse as precision medicine, clinical and translational research, pharmacology, consumer screening, and agricultural and livestock applications.

There are a large number of predefined array types of various kinds, which also offer the possibility of adding customized panel designs for specific research needs.

The widespread use of this technology encourages collaboration and accelerates research.

In addition to SNPs, it also detects chromosomal alterations and copy number variations (CNVs) simultaneously on the same array.

The workflow allows studies to be scaled from a few samples to large population studies.

Capability of integration with Illumina sequencing systems for multi-omic analysis.

It has integrated tools for laboratory management, monitoring, and traceability.

Our latest innovation: the TECAN robot

EpiDisease has the IAPS (Infinium Automated Pipetting System) platform, a high-precision instrument that automates specific steps in Illumina’s Infinium array workflows.

This automation translates into:

a significant increase in performance,
a reduction in manual handling time, and
greater experimental reproducibility,

enabling extensive studies to be carried out that were previously very costly.

EpiDisease has expanded its capacity to process all types of arrays detailed in the table below:

BovineHD DNA Analysis

Bovine genome SNP genotyping array

8 samples/array

Infinium HD

DNA: Bos taurus taurus

777,962 SNPs distributed evenly throughout the genome

Whole genome studies
Identification of quantitative trait loci
Genetic quality assessment
Cross mapping
Linkage disequilibrium studies
Comparative genetic studies

BovineSNP50 v3 DNA Analysis

Array with SNPs validated in 18 common beef and dairy cattle breeds.

24 samples/array

Infinium HTS

DNA: Bos taurus taurus

53,218 highly informative SNPs evenly distributed across the genome with an average spacing of 37.4 Kb

Genomic selection
Identification of quantitative trait loci
Genetic quality assessment

Infinium Asian Screening Array-24 v1.0

Array with informative markers for East and Southeast Asian populations that are underrepresented in reference populations.

Infinium HTS

DNA: Human

659.184 markers:

SNPs
Indels
CNVs

Population studies
Studies of complex diseases
Pharmacogenetic studies

Infinium Core-24 Kit

Cost-effective array for large-scale projects.

24 samples/array

Infinium HTS

DNA: Human

307.342 markers:

SNPs
Germline variants
Structural variants
Indels
CNVs

Estudios de variantes comunes
Estudio de ascendencia
Confirmación de sexo
Pérdida de variantes
Estudio de indels
Detección de CNVs

Infinium CytoSNP-850K Bead Chip

High-resolution array for the analysis of chromosomal aberrations in 3,262 genes relevant to cancer studies

8 samples/array

Infinium HD

DNA: Human

848.000 SNPs
3262 dose sensetive genes

CNVs
Loss of heterozygosity

Infinium Exome-24 Kit

Array of selected exonic variants from 12,000 human exomes and WGS

24 samples/array

Infinium HTS

DNA: Human

244,883 markers representing diverse populations and various common diseases, cancer, metabolic and psychiatric disorders

New studies of previously genotyped cohorts
Studies identifying functionally relevant associations

Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit

Array designed for pharmacogenomics (PGx) and large-scale genotyping studies

24 samples/array

Infinium EX

DNA: Human

1.185.155 SNP markers

Structural variants
SNVs
Indels
CNVs

Large-scale pharmacogenomics studies
Large-scale genotyping studies

Infinium Global Clinical Research Array-24 v1.0 kit

Cost-effective genotyping array for clinical research studies

24 samples/array

Infinium EX

DNA: Human

1.157.992 markers:

SNPs
Indels

Clinical research studies
Population studies
Molecular blood typing studies

Infinium Global Diversity Array with Carrier Screening Content-8 v2.0 kit

Cost-effective array for pan-ethnic screening studies of carriers of 602 genes

8 samples/array

Infinium LCG

DNA: Human

1,870,000 markers (45,000 carrier screening markers recommended by the ACMG)

SNPs
CNVs

Screening for carriers of recessive and X-linked diseases

Infinium Global Diversity Array with Cytogenetics-8

Array for cytogenetic studies

8 samples/array

Infinium LCG

DNA: Human

1.800.000 markers:

SNPs
Heterogenicity loss
Chromosomal abnormalities
CNVs

Detection of structural variants: duplications, deletions, loss of heterozygosity, and mosaicism
Studies of cytogenetic changes in constitutional diseases, cancer, etc.
Detection and validation studies

Infinium Global Diversity Array with Enhanced PGx

Very comprehensive genotyping array for pharmacogenomic research

8 samples/array

Infinium LCG

DNA: Human

1,933,117 markers:

SNPs
CNVs
Targeted amplification for pseudogene disambiguation

Pharmacogenomics research
Polygenic risk studies
Ancestry determination
Genetic disease research

Infinium Global Diversity Array with Polygenic Risk Score Content-8 v1.0

Flexible array for PRS (Polygenic Risk Score) studies

8 samples/array

Infinium LCG

DNA: Human

2,028,571 markers:

SNPs
Mitochondrial
Indels
Sex chromosomes
Pseudoautosomal regions (PAR)

Studies of polygenic diseases (diabetes, cancer, coronary heart disease, Alzheimer’s disease, etc.)
Pan-ethnic GWAS studies

Infinium Global Diversity Array-8 kit

Cost-effective multiethnic array

8 samples/array

Infinium LCG

DNA: Human

1,825,277 markers:

SNPs
Mitochondrial
Indels
Sex chromosomes
Pseudoautosomal regions (PAR)

Pharmacogenomic studies associated with absorption, distribution, metabolism, and excretion phenotypes based on PharmGKB17

Infinium Global Screening Array with Enhanced PGx-48 v4.0 Kit

High-throughput genotyping array with automated workflow

48 samples/array

Infinium EX

DNA: Human

656,275 markers:

SNPs
Mitochondrial
Indels
Sex chromosomes
Pseudoautosomal regions (PAR)

High-throughput population studies
Research in pharmacogenomics and precision medicine

Infinium Global Screening Array with Cytogenetics-24

Cost-effective array for whole-genome cytogenetic analysis

24 samples/array

Infinium HTS

DNA: Humano

700.000 marcadores

Detección de CNVs en enfermedades constitucionales y cáncer

Infinium Global Screening Array with Enhanced PGx-48 v4.0 Kit

Array de genotipado de alto rendimiento con flujo de trabajo automatizado

48 muestras/array

Infinium EX

DNA: Humano

656.275 marcadores:

SNPs
Mitocondriales
Indels
Cromosomas sexuales
Regiones pseudoautosómicas (PAR)

Estudios poblacionales de alto rendimiento
Investigación en farmacogenómica y medicina de precisión

Infinium Global Screening Array-24 kit

Array de genotipado de alto rendimiento con posibilidad de flujo de trabajo automatizado

24 muestras/array

Infinium HTS (v3.0)

DNA: Humano

654.027 marcadores

Estudios de genética de poblaciones de alto rendimiento
Screening de variantes
Estudios de medicina de precisión

Infinium Global Screening Array-48 kit

Array de genotipado de alto rendimiento con posibilidad de flujo de trabajo automatizado

48 muestras/array

Infinium EX

DNA: Humano

650.231 marcadores

Estudios de genética de poblaciones de alto rendimiento
Estudios de medicina de precisión

Infinium HTS iSelect Custom Beadchips

Array totalmente personalizado con acceso a cualquier marcador/especie totalmente personalizado para cualquier investigación

24 muestras/array

Infinium HTS

DNA: cualquier especie

Ensayos totalmente customizados para cualquier SNP, cualquier genoma y cualquier especie

Infinium ImmunoArray-24 v2 BeadChip Kit

Array de alto rendimiento para la detección de variantes genéticas en el sistema inmunitario

24 muestras/array

Infinium HTS

DNA: Humano

253.702 marcadores específicos del sistema inmune

Enfocado en 17 enfermedades autoinmunes

Infinium Methylation Screening Array-48 Kit

Array enfocado en marcadores de metilación asociados con rasgos humanos comunes

48 muestras/array

Infinium EX

DNA: Humano

269.094 marcadores islas CpG. CpH, SNPs

Estudios de MSA
Investigación de enfermedades más frequentes (no cáncer)
Epidemiología ambiental
Genómica de poblaciones
Genómica del consumidor (ancestros, edad biológica, etc.)

Infinium MethylationEPIC v2.0 Kit

Arrays de metilación del genoma completo

8 muestras/array

Infinium HD

DNA: Humano

935.000 marcadores de metilación

Análisis de metilación del genoma completo
Investigación en enfermedades genéticas raras,
Investigación en cáncer

Infinium Mouse Methylation BeadChip

Arrays de metilación de cepas murinas empleadas en laboratorios de investigación

12 muestras/array

Infinium HD

DNA: Ratón

285.000 marcadores de metilación

Estudios de cambio de metilación del DNA en cepas murinas

Infinium Omni5-4 Kit

Array que abarca todo el genoma con una alta cobertura en superpoblaciones mundiales

4 muestras/array

Infinium LCG

DNA: Humano

4.327.108 marcadores de:

SNPS
Variantes estructurales y de línea germina
Indels
CNVs

Genotipado del genoma completo
Estudios de CNVs

Infinium OmniExpress-24 Kit

Array personalizable para estudios de genotipado de alto rendimiento

24 muestras/array

Infinium HTS

DNA: Humano

717.960 marcadores

Estudios GWAS

Infinium OncoArray-500K BeadChip

Array desarrollado por el consorcio “OncoArray”

24 muestras/array

Infinium HTS

DNA: Humano

499.170 marcadores

Estudios de los cánceres más frecuentes: mama, colorrectal, pulmón, ovario y próstata

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